Séminaire virtuel: vendredi 3 décembre 2021
Manish Kushwaha (Team Bio-RetroSynth, INRAE) et Athénaïs Vaginay (capsid team CRAN/LORIA)

Lien Zoom

  • Meeting ID: 867 6409 6440
  • passcode: 149120

13h00 - 13h30 – Manish Kushwaha (Team Bio-RetroSynth, INRAE)

Bacteriophages for intercellular communication in bacterial cultures

Recent advances in biological engineering promise to deliver many high impact biotechnology solutions. However, as the engineered components increase in size they impose substantial burden on the host cells, resulting in their subsequent loss by mutation and negative selection. A possible solution involves the division of labour by distributing the engineered components into several cells. However, it brings with it the challenge of intercellular communication between the constituent cells of the consortium. We develop methods for bacterial intercellular communication that repurpose components from bacteriophage machinery to establish communication channels for distributed implementation of genetic circuits.

13h30 - 14h00 – Athénaïs Vaginay (capsid team CRAN/LORIA)

From Chemical Reaction Networks to Boolean Networks, Automatically

To understand and study biological systems it is necessary to model them within a mathematical formalism. Chemical Reaction Networks (CRN) are a widely used modelling formalism and many CRN models are available in repositories such as Biomodels. While those models can be interpreted with different semantics, Boolean Networks (BNs) are better suited in some cases. My talk is about our automatic pipeline to transforms a given CRN model to a set of compatible BNs. I will presents the steps of this pipeline and show empirical evidence that the constructed BNs are in line with the structure and the dynamics of a given CRN (i.e., they are compatible with the CRN). I will also discuss the current limitations of the pipeline.

Dernière modification le 03/12/2021