Hybrid models and methods in systems medicine

5-6 July 2022, Institut Curie
Amphitheatre Constant Burg
12 rue Lhomond, Paris

The workshop will gather researchers from biology, applied mathematics, and computer science developing hybrid models and methods for systems biology and medicine, including work around hybrid formalisms like timed and hybrid automata, the coupling of models by integrating combinatorial and continuous constraints, and the use of machine learning to design models and identify their parameters. The program will cover both theoretical aspects and concrete applications to systems biology and medicine, in the field of biological ryhthms, the immune system, metabolism, and cancer.


Registration is closed.


Tuesday 5 July

Lunch (buffet) from 11:45 to 12:40

Session Biological rythms

  • 12:45 - 12:50 Introduction
  • 12:50 - 13:30 Anne-Laure Huber (INSERM, Lyon): Defining the molecular connection between the circadian clock and NLRP3: Implication for Lung cancer treatments
  • 13:30 - 14:10 Kiran Padmanabhan (IGFL, ENS Lyon): Circadian dynamics in chromatin state
  • 14:10 - 14:30 Julien Martinelli (Aalto Univ, Finland): Model learning to identify systemic regulators of the peripheral circadian clock
    coffee break
  • 15:00 - 15:40 Samuel Bernard (CNRS, UCB, Lyon): Simuscale: A modular framework for multiscale single-cell modelling
  • 15:40 - 16:20 Madalena Chaves (Inria, Nice): Dynamics, synchronization, and oscillator interactions for models of the circadian clock
  • 16:20 - 17:00 Thao Dang (CNRS, Verimag, Grenoble): Hybrid Systems Reachability Analysis for Biological Systems Modelling

Wednesday 6 July

Session Immunity, Metabolism

  • 8:45 - 9:25 - Johnathan Pol (INSERM, Paris): Modeling of cancer immunogenic cell death
  • 9:25 - 10:05 - Vera Pancaldi (INSERM, Toulouse): Integrative regulatory models in immuno-oncology: the long path towards data-driven approaches
  • 10:05 - 10:25 - Vincent Noël (Institut Curie, Paris): PhysiBoSS, an agent-based framework with boolean intracellular signalling
    coffee break
  • 10:55 - 11:35 - Fabien Crauste (CNRS, MAP5, Paris): Differentiation, Heterogeneity, and Multiscale Descriptions of the CD8 T Cell Immune Response
  • 11:35 - 12:15 - Ovidiu Radulescu (LPHI, Univ Montpellier): Hybrid modeling at the mesoscale


Session Metabolism

  • 13:45 - 14:25 - Sophie Vasseur (INSERM, CRCM Marseille): Targeting metabolic pathways that promote pancreatic cancer cells aggressiveness
  • 14:25 - 15:05 - Angélique Stéphanou (CNRS, TIMC, Grenoble): Investigation of metabolic heterogeneity in tumor spheroids with a hybrid multi-scale model
    coffee break
  • 15:35 - 16:05 - Sabine Péres (LBBE, Univ Lyon): Hybrid metabolic modeling to identify new control strategies of living organisms
  • 16:05 - 16:25 - Kerian Thuillier (IRISA, Rennes): MERRIN: MEtabolic Regulation Rule INference from time series


Amphitheatre Constant Burg, 12 rue Lhomond, 75005 Paris

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This event is organised by Annabelle Ballesta (INSERM/Institut Curie) and Loïc Paulevé (CNRS/LaBRI) with the support of GT Bioss (CNRS), GDR IM, GDR BiM, GDR MathSAV.